法国一家医院血液科中表达金属β-内酰胺酶VIM-2的铜绿假单胞菌分离株的医院内传播。
Nosocomial spread of Pseudomonas aeruginosa isolates expressing the metallo-beta-lactamase VIM-2 in a hematology unit of a French hospital.
作者信息
Aubron Cécile, Poirel Laurent, Fortineau Nicolas, Nicolas Pierre, Collet Louis, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre cedex, France.
出版信息
Microb Drug Resist. 2005 Fall;11(3):254-9. doi: 10.1089/mdr.2005.11.254.
Dissemination of metallo-beta-lactamases (carbapenemases) was investigated retrospectively among ceftazidimeand imipenem-resistant Pseudomonas aeruginosa isolates in a hematology unit in Marseilles, France, from September, 1995, to March, 1999. Sixteen clinical isolates and 23 environmental strains were identified, with a same bla (VIM-2) gene that encoded a carbapenemase identified in Southern Europe and South Korea. Five different genotypes were identified among clinical and environmental P. aeruginosa isolates all harboring an approximately 45-kb plasmid with bla (VIM-2)-positive class 1 integrons varying in structures. This study identified a hidden reservoir of carbapenemase producers.
1995年9月至1999年3月期间，在法国马赛一家血液科，对耐头孢他啶和亚胺培南的铜绿假单胞菌分离株中金属β-内酰胺酶（碳青霉烯酶）的传播情况进行了回顾性研究。共鉴定出16株临床分离株和23株环境菌株，它们具有相同的bla（VIM-2）基因，该基因编码一种在南欧和韩国发现的碳青霉烯酶。在临床和环境铜绿假单胞菌分离株中鉴定出五种不同的基因型，所有分离株均携带一个约45kb的质粒，其上带有结构各异的bla（VIM-2）阳性1类整合子。本研究发现了碳青霉烯酶产生菌的一个隐藏来源。
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