Peptide triazole inactivators of HIV-1: how do they work and what is their potential?
作者信息
Chaiken Irwin, Rashad Adel A
机构信息
Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
出版信息
Future Med Chem. 2015;7(17):2305-10. doi: 10.4155/fmc.15.152. Epub 2015 Nov 24.
Abstract
摘要
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Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.大环HIV-1灭活剂的化学优化，以提高效力并增加三唑环处的结构多样性。
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本文引用的文献
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Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols.Env蛋白中的二硫键敏感性是肽基三唑硫醇对HIV-1进行裂解失活的基础。
ACS Chem Biol. 2015 Dec 18;10(12):2861-73. doi: 10.1021/acschembio.5b00381. Epub 2015 Oct 22.
2
Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter.在宿主细胞接触前不可逆地使HIV-1失活的大环包膜糖蛋白拮抗剂。
J Med Chem. 2015 Sep 24;58(18):7603-8. doi: 10.1021/acs.jmedchem.5b00935. Epub 2015 Sep 11.
3
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.成熟的无配体HIV-1包膜糖蛋白的晶体结构、构象固定及与进入相关的相互作用
Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun 22.
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Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition.单个HIV-1糖蛋白41复合物在病毒膜融合与抑制过程中的动力学偶联折叠。
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2855-64. doi: 10.1073/pnas.1424995112. Epub 2015 May 18.
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Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.HIV-1的肽基三唑失活剂利用Env gp120内外结构域交界处保守的双腔结合位点。
J Med Chem. 2015 May 14;58(9):3843-58. doi: 10.1021/acs.jmedchem.5b00073. Epub 2015 Apr 28.
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HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth.作为治疗靶点的HIV-1 gp120：在动态迷宫中探索
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