Avramova Boryana E, Hristova Tanya, Yordanova Maya, Vlahova Irena, Muchinova Albena, Bojinova Veneta, Konstantinov Dobrin
*Specialized Hospital for Pediatric Oncohaematology †Multispecialty Hospitals for Active Treatment in Neurology and Psychiatry "Saint Naum", Sofia, Bulgaria.
J Pediatr Hematol Oncol. 2016 Aug;38(6):470-2. doi: 10.1097/MPH.0000000000000486.
We report a rare case of cerebellar degeneration as a paraneoplastic syndrome in an 8-year-old boy with Hodgkin lymphoma that presented during first-line treatment. Antibodies against Purkinje cells (anti-Tr antibodies) were detected in the serum of the patient. After successful treatment of the lymphoma, the cerebellar symptoms resolved partially. Childhood presentation of paraneoplastic cerebellar degeneration is extremely rare, with only a few reports in the literature. For this reason, the description of all such cases contributes to the enrichment of the medical knowledge and will improve the diagnosis and the treatment of this complication.
我们报告了一例罕见的小脑变性病例，该病例为一名8岁患有霍奇金淋巴瘤的男孩在一线治疗期间出现的副肿瘤综合征。在患者血清中检测到抗浦肯野细胞抗体（抗Tr抗体）。淋巴瘤成功治疗后，小脑症状部分缓解。儿童期出现副肿瘤性小脑变性极为罕见，文献中仅有少数报道。因此，对所有此类病例的描述有助于丰富医学知识，并将改善对这种并发症的诊断和治疗。
