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霍奇金病伴小脑变性:一项免疫学研究

Cerebellar degeneration with Hodgkin disease. An immunological study.

作者信息

Trotter J L, Hendin B A, Osterland C K

出版信息

Arch Neurol. 1976 Sep;33(9):660-1. doi: 10.1001/archneur.1976.00500090066014.

DOI:10.1001/archneur.1976.00500090066014
PMID:962649
Abstract

A 21-year-old woman with subacute cerebellar degeneration was found to have Hodgkin lymphoma. Radiation therapy for the lymphoma halted the progression of her neurological disease. Using an immunofluorescent technique, we found the patient's serum to have antibodies to cerebellar Purkinje cells.

摘要

一名患有亚急性小脑变性的21岁女性被发现患有霍奇金淋巴瘤。针对淋巴瘤的放射治疗阻止了她神经系统疾病的进展。通过免疫荧光技术,我们发现患者血清中存在针对小脑浦肯野细胞的抗体。

相似文献

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Cerebellar degeneration with Hodgkin disease. An immunological study.霍奇金病伴小脑变性:一项免疫学研究
Arch Neurol. 1976 Sep;33(9):660-1. doi: 10.1001/archneur.1976.00500090066014.
2
Ovarian carcinoma and paraneoplastic cerebellar degeneration.卵巢癌与副肿瘤性小脑变性
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Anti-Purkinje cell antibody producing B-cell lines from a patient with paraneoplastic cerebellar degeneration.从一名副肿瘤性小脑变性患者中分离出的产生抗浦肯野细胞抗体的B细胞系。
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Cerebellar Degeneration as a Rare Paraneoplastic Syndrome in a Child With Hodgkin Lymphoma.小脑变性作为霍奇金淋巴瘤患儿罕见的副肿瘤综合征
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Autoantibodies in paraneoplastic cerebellar degeneration bind to cytoplasmic antigens of Purkinje cells in humans, rats and mice and are of multiple immunoglobulin classes.副肿瘤性小脑变性中的自身抗体可与人、大鼠和小鼠浦肯野细胞的胞质抗原结合,且具有多种免疫球蛋白类别。
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J Neurol. 1991 Aug;238(5):288-92. doi: 10.1007/BF00319741.

引用本文的文献

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2
Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma.抗Tr/DNER抗体相关副肿瘤性神经系统综合征伴间变性大细胞淋巴瘤并表现为边缘叶脑炎
Intern Med. 2025 Jul 1;64(13):2057-2061. doi: 10.2169/internalmedicine.4530-24. Epub 2024 Dec 12.
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Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy.
免疫治疗治疗非副肿瘤性 DNER 共济失调病例的良好结果。
Cerebellum. 2024 Aug;23(4):1697-1701. doi: 10.1007/s12311-023-01636-z. Epub 2023 Nov 22.
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Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology.与抗浦肯野细胞抗体相关的自身免疫性小脑共济失调:神经免疫学的新前沿
Ann Transl Med. 2023 Apr 15;11(7):285. doi: 10.21037/atm-20-2187. Epub 2021 Jul 21.
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Biomedicines. 2022 Dec 25;11(1):44. doi: 10.3390/biomedicines11010044.
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