Krause Neto Walter, Ciena Adriano Polican, Anaruma Carlos Alberto, de Souza Romeu Rodrigues, Gama Eliane Florencio
Laboratory of Morphoquantitative Studies and Immunohistochemistry, Physical Education Department, São Judas Tadeu University, Unidade Mooca, Rua Taquari, 546, Mooca, P.O Box: 03166-000, São Paulo, SP, Brazil.
Laboratory of Histology and Electron Microscopy, Physical Education Department, "Julio de Mesquita Filho" São Paulo State University, Rio Claro, SP, Brazil.
BMC Res Notes. 2015 Nov 24;8:713. doi: 10.1186/s13104-015-1644-4.
During almost one-third of our life, maturation of the nervous system promotes strength and muscle mass increase. However, as age advances, the nervous system begins to suffer a slow and continue reduction of its functions. Neuromuscular junction (NMJ) is one of the structures of which change due to aging process. Physical training leads to significant adjustments in NMJs of young and aged animals. Nevertheless, studies that aimed to investigate this effect have, in many cases, methodological variables that may have some influence on the result. Thus, this study aimed to carry out a systematic review about the effects of exercise training on the NMJ compartments of young, adult and aged animals.
We searched PubMed, Google Scholar, Science Direct, Scielo and Lilacs databases for animal experimental studies that studied exercise effects on the NMJs components across age. After inclusion and exclusion criteria, we included nine articles in systematic review and two for meta-analysis (young/adult NMJ).
We identified that exercise training cause NMJ hypertrophy on young animals and NMJ compression on aged ones. However, many methodological issues such as age, skeletal muscle and fibers type, and type of exercise and training protocol might influence the results. Graphical abstract: Flow gram is actually to be show at results section as Fig 1.
在我们生命的近三分之一时间里，神经系统的成熟促进力量和肌肉量增加。然而，随着年龄增长，神经系统开始遭受其功能的缓慢且持续的衰退。神经肌肉接头（NMJ）是因衰老过程而发生变化的结构之一。体育锻炼会导致年轻和老年动物的神经肌肉接头发生显著改变。然而，旨在研究这种影响的研究在很多情况下存在可能对结果产生一定影响的方法学变量。因此，本研究旨在对运动训练对年轻、成年和老年动物神经肌肉接头各部分的影响进行系统综述。
我们在PubMed、谷歌学术、科学Direct、Scielo和Lilacs数据库中搜索了关于运动对不同年龄段动物神经肌肉接头成分影响的动物实验研究。经过纳入和排除标准筛选后，我们纳入了9篇文章进行系统综述，2篇进行荟萃分析（年轻/成年神经肌肉接头）。
我们发现运动训练会导致年轻动物的神经肌肉接头肥大，老年动物的神经肌肉接头受压。然而，许多方法学问题，如年龄、骨骼肌和纤维类型，以及运动类型和训练方案，可能会影响结果。图形摘要：流程图实际上应在结果部分作为图1展示。
