Kryl'skii E D, Popova T N, Kirilova E M
Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia.
Voronezh Regional Clinical Diagnostic Center, Voronezh, Russia.
Bull Exp Biol Med. 2015 Nov;160(1):24-7. doi: 10.1007/s10517-015-3089-0. Epub 2015 Nov 25.
Induction of rheumatoid arthritis in rats was accompanied by an increase in diene conjugate content and glutathione reductase and glutathione peroxidase activities in muscles and blood serum. These changes can be related to mobilization of the glutathione reductase/glutathione peroxidase system coupled with intensification of free radical oxidation. In addition, activity of glucose-6-phosphodehydrogenase and NADP-dependent isocitrate dehydrogenase increased, which can be related to increased demand of NADPH for the glutathione reductase/glutathione peroxidase system. The content of reduced glutathione in muscles and blood serum decreased, probably, due to its utilization for ROS neutralization. Glutathione transferase activity decreased in rheumatoid arthritis, which can be related to shortness of reduced glutathione developing during oxidative stress. The observed shifts in parameters of free radical homeostasis in rheumatoid arthritis are probably associated with intensification of free radical oxidation.
大鼠类风湿性关节炎的诱导伴随着肌肉和血清中二烯共轭物含量以及谷胱甘肽还原酶和谷胱甘肽过氧化物酶活性的增加。这些变化可能与谷胱甘肽还原酶/谷胱甘肽过氧化物酶系统的动员以及自由基氧化的增强有关。此外，葡萄糖-6-磷酸脱氢酶和NADP依赖性异柠檬酸脱氢酶的活性增加，这可能与谷胱甘肽还原酶/谷胱甘肽过氧化物酶系统对NADPH的需求增加有关。肌肉和血清中还原型谷胱甘肽的含量可能由于其用于中和活性氧而降低。类风湿性关节炎中谷胱甘肽转移酶活性降低，这可能与氧化应激期间还原型谷胱甘肽的短缺有关。类风湿性关节炎中自由基稳态参数的观察到的变化可能与自由基氧化的增强有关。
