Tkachenko V, Kovalchuk Y, Bondarenko N, Bondarenko О, Ushakova G, Shevtsova A
SI "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine", Dnipro, Ukraine.
Oles Honchar Dnipro National University, Dnipro, Ukraine.
Biochem Res Int. 2018 Sep 3;2018:9302414. doi: 10.1155/2018/9302414. eCollection 2018.
Heart diseases, especially acute coronary syndrome (ACS), are among the most severe illnesses that often lead to death. Despite significant advances in the prevention and treatment of ACS, the incidence of the disease and its complications are very serious. The imbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation in the blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioral responses. So, the search for antioxidants with cardio- and neuroprotective effects is an urgent task. This study was aimed at evaluating the effects of Corvitin and 2-oxoglutarate on physiological parameters, heart histology, and markers of carbonyl/oxidative stress of rats with pituitrin-isoproterenol-induced myocardial damage (PIMD). Increased sweating, tachycardia, significantly decreased locomotor and exploratory activity, changes of ECG, heart histology, and biochemical changes were observed in the PIMD-group. The administration of Corvitin or 2-OG led to the recovery of locomotor and cognitive activities of the rats, improvement in heart histology, a decrease in the levels of thiobarbituric acid reactive substances, advanced glycated end products, and various changes in the activity of the antioxidant enzymes, 6 days after PIMD. So, Corvitin and exogenous 2-OG show cardio- and neuroprotective effects through the decrease of carbonyl/oxidative stress and regulation of the activity of the antioxidant system.
心脏病，尤其是急性冠状动脉综合征（ACS），是最严重的疾病之一，常常导致死亡。尽管在ACS的预防和治疗方面取得了重大进展，但该疾病及其并发症的发病率仍然非常严重。血液和组织中促氧化与抗氧化系统之间的失衡、活性羰基化合物的形成以及糖基化终产物是导致心脏和神经功能障碍并引起行为反应改变的关键因素。因此，寻找具有心脏和神经保护作用的抗氧化剂是一项紧迫的任务。本研究旨在评估Corvitin和2-氧代戊二酸对垂体后叶素-异丙肾上腺素诱导的心肌损伤（PIMD）大鼠的生理参数、心脏组织学以及羰基/氧化应激标志物的影响。在PIMD组中观察到出汗增加、心动过速、运动和探索活动显著减少、心电图改变、心脏组织学变化以及生化改变。在PIMD发生6天后，给予Corvitin或2-OG可使大鼠的运动和认知活动恢复，心脏组织学改善，硫代巴比妥酸反应性物质、晚期糖基化终产物水平降低，抗氧化酶活性发生各种变化。因此，Corvitin和外源性2-OG通过降低羰基/氧化应激以及调节抗氧化系统的活性而显示出心脏和神经保护作用。
