Safonova O A, Popova T N, Panchenko L F
Department of Medical Biochemistry and Microbiology, Voronezh State University, Moscow, Russia.
Bull Exp Biol Med. 2011 Sep;151(5):556-9. doi: 10.1007/s10517-011-1381-1.
We studied the effects of dimethoxyphenyl biguanide on glutathione peroxidase and glutathione reductase activities, level of reduced glutathione in rat tissues, and activity of some NADPH-regenerating enzymes (glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase) under conditions of ischemia-reperfusion of the brain. Administration of this biguanide derivative under pathological conditions led to a decrease in the analyzed parameters (elevated under conditions of ischemia-reperfusion) in the serum and brain tissue. The results attest to less pronounced mobilization of the glutathione system (compared to pathological state) due to antioxidant and protective properties of 2,4-dimethoxyphenyl biguanide under conditions of ischemic tissue damage associated with oxidative stress.
我们研究了二甲氧基苯基双胍对大鼠脑组织缺血再灌注条件下谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性、大鼠组织中还原型谷胱甘肽水平以及一些NADPH再生酶（葡萄糖-6-磷酸脱氢酶和NADP-异柠檬酸脱氢酶）活性的影响。在病理条件下给予这种双胍衍生物会导致血清和脑组织中所分析参数（在缺血再灌注条件下升高）降低。结果表明，在与氧化应激相关的缺血性组织损伤条件下，由于2,4-二甲氧基苯基双胍的抗氧化和保护特性，谷胱甘肽系统的动员作用（与病理状态相比）不太明显。
