El-Menyar Ayman, Asim Mohammad, Latifi Rifat, Al-Thani Hassan
Clinical Medicine, Weill Cornell Medical College, Doha, Qatar.
Clinical Research, Trauma Surgery Section, Hamad General Hospital, PO Box 3050, Doha, Qatar.
Sci Eng Ethics. 2016 Dec;22(6):1605-1626. doi: 10.1007/s11948-015-9730-5. Epub 2015 Nov 24.
Research is an integral part of evidence-based practice in the emergency department and critical care unit that improves patient management. It is important to understand the need and major obstacles for conducting research in emergency settings. Herein, we review the literature for the obligations, ethics and major implications of emergency research and the associated limiting factors influencing research activities in critical care and emergency settings. We reviewed research engines such as PubMed, MEDLINE, and EMBASE for the last two decades using the key words "emergency department", "critical care", "research", "consent", and "ethics" as the search terms. Research within emergency settings is slow or non-existent due to time and financial constraints as well as the lack of a research tradition. There are several barriers to conducting research studies in emergency situations such as who, what, when, and how to obtain patient consent. The emergency environment is highly pressurized, emotional, and overburdened. The time taken for research is a particular risk that could delay the desired immediate interventions. Ethical issues abound, particularly relating to informed consent. Research in emergency settings is still in its infancy. Thus, there is a strong need for extensive research in the emergency setting through community awareness, resource management, ethics, collaborations, capacity building, and the development of a research interest for the improvement of patient care and outcomes. We need to establish a well-structured plan to assess and track the decision-making capacity, consider a multistep enrolment and consent strategy, and develop an integrated approach for recruitment into studies.
研究是急诊科和重症监护病房循证实践的重要组成部分,有助于改善患者管理。了解在急诊环境中开展研究的必要性和主要障碍很重要。在此,我们回顾文献,探讨急诊研究的义务、伦理及主要影响,以及影响重症监护和急诊环境中研究活动的相关限制因素。我们使用关键词“急诊科”“重症监护”“研究”“同意”和“伦理”,在过去二十年里检索了诸如PubMed、MEDLINE和EMBASE等研究引擎。由于时间和资金限制以及缺乏研究传统,急诊环境中的研究进展缓慢或不存在。在紧急情况下开展研究存在诸多障碍,比如谁、什么、何时以及如何获得患者同意。急诊环境压力巨大、情绪紧张且负担过重。研究所需时间是一个特别的风险因素,可能会延迟所需的即时干预措施。伦理问题比比皆是,尤其是与知情同意相关的问题。急诊环境中的研究仍处于起步阶段。因此,迫切需要通过提高社区意识、资源管理、伦理、合作、能力建设以及培养研究兴趣,在急诊环境中开展广泛研究,以改善患者护理和治疗结果。我们需要制定一个结构完善的计划,以评估和跟踪决策能力,考虑采用多步骤入组和同意策略,并制定一种综合的研究招募方法。