Seyfeli Ergun, Sarli Bahadir, Saglam Hayrettin, Karatas Can Y, Ozkan Eyup, Ugurlu Mehmet
Department of Cardiology, School of Medicine, Acibadem University, Istanbul, Turkey.
Department of Cardiology, Research and Education Hospital, Kayseri, Turkey.
J Clin Hypertens (Greenwich). 2016 Jul;18(7):679-84. doi: 10.1111/jch.12734. Epub 2015 Nov 24.
The authors aimed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and presence of left ventricular hypertrophy and diastolic dysfunction in patients with hypertension. A total of 95 newly diagnosed hypertensive patients (mean age, 54±10 years) and 20 controls were included in this study. Patients were divided into four groups according to relative wall thickness as normal, concentric remodeling, concentric, and eccentric hypertrophy. hs-CRP was measured in all patients and serum hs-CRP level was shown to be increased in patients with hypertension compared with controls (0.57 mg/dL vs 0.25 mg/dL, respectively; P<.001). The hs-CRP level was highest in patients with concentric hypertrophy. When compared with controls, serum hs-CRP level was significantly higher in patients with concentric remodeling (0.61±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.030) and concentric hypertrophy (0.69±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.032). The present study shows that serum hs-CRP is significantly associated with left ventricular diastolic function and concentric hypertrophy in patients with hypertension.
作者旨在评估高血压患者中高敏C反应蛋白(hs-CRP)与左心室肥厚及舒张功能障碍之间的关系。本研究共纳入95例新诊断的高血压患者(平均年龄54±10岁)和20例对照。根据相对室壁厚度将患者分为四组,即正常、向心性重构、向心性肥厚和离心性肥厚。对所有患者均检测了hs-CRP,结果显示高血压患者的血清hs-CRP水平高于对照组(分别为0.57 mg/dL和0.25 mg/dL;P<0.001)。向心性肥厚患者的hs-CRP水平最高。与对照组相比,向心性重构患者(0.61±0.3 mg/dL对0.43±0.5 mg/dL,P<0.030)和向心性肥厚患者(0.69±0.3 mg/dL对0.43±0.5 mg/dL,P<0.032)的血清hs-CRP水平显著更高。本研究表明,血清hs-CRP与高血压患者的左心室舒张功能及向心性肥厚显著相关。