Rajawat Neelu Kanwar, Soni Inderpal, Syed Farah, Verma Rajbala, John P J, Mathur Reena
1 Department of Zoology, The IIS University, Jaipur, India.
2 Environmental Toxicology Lab, Department of Zoology, University of Rajasthan, Jaipur, India.
Toxicol Ind Health. 2019 May;35(5):358-367. doi: 10.1177/0748233719840957.
The present study was planned to evaluate neurotoxic effects of β-cyfluthrin in female Swiss albino mice. Two doses of β-cyfluthrin, specifically, one-tenth of median lethal dose (LD) and one-twentieth of LD, were selected for the study. Open-field behaviour, exploratory behaviour and emotional status were affected, and animals showed anxiety-like behaviour after β-cyfluthrin administration. Spatial learning was decreased using the Hebb-Wiliams maze. Acetylcholinesterase enzyme activity significantly decreased in the treated animals. The administration of β-cyfluthrin caused increased lipid peroxidation (malondialdehyde) and decreased superoxide dismutase, catalase and glutathione peroxidase activity in brain tissue. In conclusion, β-cyfluthrin caused neurotoxicity as well as oxidative damage in the brain of Swiss albino mice at the tested dose levels.
本研究旨在评估β-氯氟氰菊酯对雌性瑞士白化小鼠的神经毒性作用。本研究选择了两个剂量的β-氯氟氰菊酯，具体为半数致死剂量（LD）的十分之一和二十分之一。旷场行为、探究行为和情绪状态均受到影响，β-氯氟氰菊酯给药后动物表现出焦虑样行为。使用赫布-威廉姆斯迷宫测试发现空间学习能力下降。受试动物的乙酰胆碱酯酶活性显著降低。β-氯氟氰菊酯给药导致脑组织中脂质过氧化（丙二醛）增加，超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性降低。总之，在测试剂量水平下，β-氯氟氰菊酯对瑞士白化小鼠的大脑造成了神经毒性以及氧化损伤。
