健康状态下的β-连环蛋白：综述
β catenin in health: A review.
作者信息
Prakash Sharada, Swaminathan Uma
机构信息
Department of Oral and Maxillofacial Pathology, AECS Maaruti College of Dental Sciences, Bengaluru, Karnataka, India.
出版信息
J Oral Maxillofac Pathol. 2015 May-Aug;19(2):230-8. doi: 10.4103/0973-029X.164537.
Abstract
β catenin belongs to the armadillo family of proteins. It plays a crucial role in developmental and homeostatic processes. Wnts are a family of 19 secreted glycoproteins that transduce multiple signaling cascades, including the canonical Wnt/β catenin pathway, Wnt/Ca(2+) pathway and the Wnt/polarity pathway. This is a review on β catenin, Wnt proteins and their secretion, the signaling pathway, the associated factors and the crucial role of β catenin in odontogenesis.
摘要
β-连环蛋白属于犰狳蛋白家族。它在发育和稳态过程中起着至关重要的作用。Wnt蛋白是一个由19种分泌型糖蛋白组成的家族，可转导多种信号级联反应，包括经典的Wnt/β-连环蛋白信号通路、Wnt/Ca(2+)信号通路和Wnt/极性信号通路。本文综述了β-连环蛋白、Wnt蛋白及其分泌、信号通路、相关因子以及β-连环蛋白在牙齿发育中的关键作用。
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