用于治疗风湿性多肌痛和巨细胞动脉炎的糖皮质激素。
Glucocorticoids for Management of Polymyalgia Rheumatica and Giant Cell Arteritis.
作者信息
Matteson Eric L, Buttgereit Frank, Dejaco Christian, Dasgupta Bhaskar
机构信息
Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55902, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55902, USA.
Department of Rheumatology and Clinical Immunology, Charité University Medicine, Charitéplatz 1, Berlin 10117, Germany.
出版信息
Rheum Dis Clin North Am. 2016 Feb;42(1):75-90, viii. doi: 10.1016/j.rdc.2015.08.009.
Diagnosis of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) is based on typical clinical, histologic, and laboratory features. Ultrasonographic imaging in PMR with assessment especially of subdeltoid bursitis can aid in diagnosis and in following response to treatment. In GCA, diagnosis and disease activity are supported with ultrasonographic, MRI, or [(18)F]fluorodeoxyglucose PET evaluation of large vessels. Glucocorticoids are the primary therapy for PMR and GCA. Methotrexate may be used in patients at high risk for glucocorticoid adverse effects and patients with frequent relapse or needing protracted therapy. Other therapeutic approaches including interleukin 6 antagonists are under evaluation.
风湿性多肌痛（PMR）和巨细胞动脉炎（GCA）的诊断基于典型的临床、组织学和实验室特征。PMR的超声成像，特别是对肩峰下滑囊炎的评估，有助于诊断和观察治疗反应。在GCA中，通过对大血管的超声、MRI或[（18）F]氟脱氧葡萄糖PET评估来支持诊断和疾病活动度判断。糖皮质激素是PMR和GCA的主要治疗方法。甲氨蝶呤可用于有糖皮质激素不良反应高风险的患者以及频繁复发或需要长期治疗的患者。包括白细胞介素6拮抗剂在内的其他治疗方法正在评估中。
Zotero 插件