Fazilat Sutude, Tahmasbi Fateme, Mirzaei Mohammad Reza, Sanaie Sarvin, Yousefi Zahra, Asnaashari Solmaz, Yaqoubi Shadi, Banagozar Mohammadi Ahad, Araj-Khodaei Mostafa
Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts. 2024 Aug 11;15:30532. doi: 10.34172/bi.30532. eCollection 2025.
The use of medicinal plants in the management of depression, also known as phytotherapy or herbal medicine for depression, is an area of growing interest in the field of mental health and complementary medicine.
This study used a systematic assessment of pertinent literature to assess the effectiveness of medicinal herbs in treating mild to severe depression. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) that reported data on the intervention, control group, adverse events, outcome measurements, and main findings. A summary and analysis were done on the included research data.
We included 23 RCTs investigating the efficacy of herbal medicines, including and , in treating depression. In general, saffron showed encouraging outcomes when used to treat mild to severe depression. With no discernible variations in the reported adverse effects, it proved to be equally efficacious as well-known antidepressants like imipramine and fluoxetine. However, it is noteworthy that not all trials yielded favorable results.
More investigation is required to fully understand the mechanisms of action, ideal dosage schedules, long-term effects, and relative efficacy of medicinal plants in depressive treatment.
药用植物在抑郁症治疗中的应用，也被称为植物疗法或抑郁症草药医学，是心理健康和补充医学领域中日益受到关注的一个领域。
本研究采用对相关文献的系统评估，以评估草药治疗轻至重度抑郁症的有效性。进行了全面的文献检索，以识别报告了干预措施、对照组、不良事件、结果测量和主要发现数据的随机对照试验（RCT）。对纳入的研究数据进行了总结和分析。
我们纳入了23项研究草药治疗抑郁症疗效的随机对照试验，包括[具体草药名称1]和[具体草药名称2]。总体而言，藏红花用于治疗轻至重度抑郁症时显示出令人鼓舞的效果。在报告的不良反应方面没有明显差异，它被证明与丙咪嗪和氟西汀等知名抗抑郁药同样有效。然而，值得注意的是，并非所有试验都产生了有利的结果。
需要更多的研究来充分了解药用植物在抑郁症治疗中的作用机制、理想剂量方案、长期影响和相对疗效。
