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“高危”小儿肾肿瘤的当前治疗标准及未来方向：间变性肾母细胞瘤和横纹肌样瘤

Current standards of care and future directions for "high-risk" pediatric renal tumors: Anaplastic Wilms tumor and Rhabdoid tumor.

作者信息

Geller James I

机构信息

Division of Oncology, Cincinnati Children׳s Hospital Medical Center, University of Cincinnati, Cincinnati, OH.

出版信息

Urol Oncol. 2016 Jan;34(1):50-6. doi: 10.1016/j.urolonc.2015.10.012. Epub 2015 Nov 21.

DOI:10.1016/j.urolonc.2015.10.012
PMID:26612481
Abstract

'High risk' renal tumors of childhood generally includes anaplastic Wilms tumor, rhabdoid tumor, and metastatic renal sarcomas and carcinomas. In this review, the epidemiology, biology, treatment and prognosis of anaplastic Wilms tumor and rhabdoid tumor are presented. Future directions related to management of such cancers are discussed, with insights provided into possible clinical trials in development that consider integration of novel targeted therapies.

摘要

儿童“高危”肾肿瘤通常包括间变性肾母细胞瘤、横纹肌样瘤以及转移性肾肉瘤和癌。在本综述中，介绍了间变性肾母细胞瘤和横纹肌样瘤的流行病学、生物学特性、治疗方法及预后情况。讨论了此类癌症治疗的未来方向，并深入探讨了正在开展的可能整合新型靶向治疗的临床试验。

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