Frierson H F, Innes D J, Mills S E, Wick M R
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.
Hum Pathol. 1989 Jul;20(7):636-42. doi: 10.1016/0046-8177(89)90150-0.
A panel of paraffin effective antibodies recognizing B cells and T cells (LN-2, MB1, L26, MT1, UCHL1, kappa, lambda) was used to characterize the immunophenotypes of 26 sinonasal non-Hodgkin's lymphomas. Seventeen tumors were stage I, five were stage II, one was stage III, and three were stage IV. Nine lymphomas were classified morphologically as large cell, six were large cell immunoblastic, six were small cleaved cell, two were mixed small and large cell, two were small noncleaved cell, and one was lymphoblastic. None were follicular. Twenty-two lymphomas had a B cell immunophenotype, three were T cell neoplasms, and one was immunoreactive only for MT1. This predominance of sinonasal lymphomas with a B cell immunophenotype in patients residing in the United States contrasts with the almost exclusive occurrence of T cell sinonasal lymphomas in Chinese patients living in Hong Kong and Japanese patients residing in regions of Japan that are nonendemic for human T cell leukemia virus-1.
使用一组识别B细胞和T细胞的石蜡有效抗体（LN-2、MB1、L26、MT1、UCHL1、κ、λ）对26例鼻窦非霍奇金淋巴瘤的免疫表型进行特征分析。17例肿瘤为I期，5例为II期，1例为III期，3例为IV期。9例淋巴瘤形态学上分类为大细胞型，6例为大细胞免疫母细胞型，6例为小裂细胞型，2例为小细胞和大细胞混合型，2例为小无裂细胞型，1例为淋巴母细胞型。均无滤泡型。22例淋巴瘤具有B细胞免疫表型，3例为T细胞肿瘤，1例仅对MT1呈免疫反应性。居住在美国的患者中鼻窦淋巴瘤以B细胞免疫表型为主，这与居住在香港的中国患者和居住在日本非人类T细胞白血病病毒1流行地区的日本患者中几乎仅发生T细胞鼻窦淋巴瘤形成对比。
