O'Leary G, Kennedy S M
Department of Pathology, Research Foundation, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
J Clin Pathol. 1995 Oct;48(10):946-9. doi: 10.1136/jcp.48.10.946.
To investigate whether non-Hodgkin's lymphomas arising in the sinonasal region or Waldeyer's ring contain the Epstein-Barr virus (EBV) genome in lesional tissue.
Sections from paraffin wax blocks of 22 lymphoid proliferations arising in the sinonasal region or Waldeyer's ring were studied with EBV encoded RNAs (EBER-1 and -2) using in situ hybridisation.
EBV was detected in nuclei of tumour cells of five of seven T cell lymphomas and in nuclei of two of seven diffuse, large cell immunoblastic lymphomas of B phenotype in the sinonasal region. Of tumours arising in Waldeyer's ring, two of 10 non-Hodgkin's lymphomas (both large cell) were positive, as was a single case of Hodgkin's disease. Lymphoma of other types, including Western type Burkitt's lymphoma, and nodular and diffuse small cleaved cell lymphoma, were negative.
EBV is highly associated with large cell lymphomas especially T cell lymphomas of sinonasal origin in the indigenous Irish population, underlining the importance of this virus in nasopharyngeal lymphomas in Northern European as well as Asian populations.
研究起源于鼻窦区域或瓦尔代尔环的非霍奇金淋巴瘤在病变组织中是否含有爱泼斯坦-巴尔病毒（EBV）基因组。
采用原位杂交技术，利用EBV编码RNA（EBER-1和-2）对22例起源于鼻窦区域或瓦尔代尔环的淋巴样增生石蜡块切片进行研究。
在鼻窦区域，7例T细胞淋巴瘤中的5例肿瘤细胞核以及7例B表型弥漫性大细胞免疫母细胞淋巴瘤中的2例肿瘤细胞核中检测到EBV。在瓦尔代尔环发生的肿瘤中，10例非霍奇金淋巴瘤（均为大细胞型）中有2例呈阳性，1例霍奇金病呈阳性。其他类型的淋巴瘤，包括西方型伯基特淋巴瘤、结节性和弥漫性小裂细胞淋巴瘤，均为阴性。
在爱尔兰本土人群中，EBV与大细胞淋巴瘤尤其是鼻窦起源的T细胞淋巴瘤高度相关，这凸显了该病毒在北欧以及亚洲人群鼻咽癌淋巴瘤中的重要性。
