Dehghan Mojdeh, Tantbirojn Daranee, Kymer-Davis Emily, Stewart Colette W, Zhang Yanhui H, Versluis Antheunis, Garcia-Godoy Franklin
Department of Restorative Dentistry, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, USA.
Summer Research Program, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, USA.
J Investig Clin Dent. 2017 May;8(2). doi: 10.1111/jicd.12198. Epub 2015 Nov 30.
The aim of the present study was to test the neutralizing effect of mouthwashes on salivary pH after an acidic challenge.
Twelve participants were recruited for three visits, one morning per week. Resting saliva was collected at baseline and after 2-min swishing with 20 mL orange juice as an acidic challenge. Participants then rinsed their mouth for 30 s with 20 mL water (control), an over-the-counter mouthwash (Listerine), or a two-step mouthwash, randomly assigned for each visit. Saliva was collected immediately, 15, and 45 min after rinsing. The pH values of the collected saliva were measured and analyzed with anova, followed by Student-Newman-Keuls post-hoc test (significance level: 0.05).
Orange juice significantly lowered salivary pH. Immediately after rinsing, Listerine and water brought pH back to baseline values, with the pH significantly higher in the Listerine group. The two-step mouthwash raised pH significantly higher than Listerine and water, and higher than the baseline value. Salivary pH returned to baseline and was not significantly different among groups at 15 and 45 min post-rinsing.
Mouth rinsing after an acidic challenge increased salivary pH. The tested mouthwashes raised pH higher than water. Mouthwashes with a neutralizing effect can potentially reduce tooth erosion from acid exposure.
本研究旨在测试漱口水在酸性刺激后对唾液pH值的中和作用。
招募12名参与者，分三次就诊，每周上午就诊一次。在基线时以及用20毫升橙汁进行2分钟含漱作为酸性刺激后收集静息唾液。然后，参与者用20毫升水（对照）、非处方漱口水（李施德林）或两步漱口水进行30秒漱口，每次就诊时随机分配。漱口后立即、15分钟和45分钟收集唾液。测量收集到的唾液的pH值，并用方差分析进行分析，随后进行Student-Newman-Keuls事后检验（显著性水平：0.05）。
橙汁显著降低了唾液pH值。漱口后立即，李施德林和水使pH值恢复到基线值，李施德林组的pH值显著更高。两步漱口水使pH值升高的幅度显著高于李施德林和水，且高于基线值。漱口后15分钟和45分钟时，唾液pH值恢复到基线，各组之间无显著差异。
酸性刺激后漱口可提高唾液pH值。所测试的漱口水使pH值升高的幅度高于水。具有中和作用的漱口水可能会减少因酸暴露导致的牙齿侵蚀。
