Moumène Amal, Meyer Damien F
CIRAD, UMR CMAEE, Site de Duclos, Prise d'eau, F-97170 Petit-Bourg, Guadeloupe, France; INRA, UMR1309 CMAEE, F-34398 Montpellier, France; Université des Antilles et de la Guyane, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
CIRAD, UMR CMAEE, Site de Duclos, Prise d'eau, F-97170 Petit-Bourg, Guadeloupe, France; INRA, UMR1309 CMAEE, F-34398 Montpellier, France.
Microbes Infect. 2016 Mar;18(3):172-9. doi: 10.1016/j.micinf.2015.11.001. Epub 2015 Nov 23.
Ehrlichia is a large genus of obligate intracellular Gram-negative bacteria transmitted by ticks that cause several emerging infectious diseases in humans and are pathogenic on rodents, ruminants, and dogs. Ehrlichia spp. invade and replicate either in endothelial cells, white blood cells, or within midgut cells and salivary glands of their vector ticks. In this review, we discuss the insights that functional studies are providing on how this group of bacteria exploits their host by subverting host innate immunity and hijacking cellular processes.
埃立克体属是一类专性细胞内革兰氏阴性菌的大属，通过蜱传播，可导致人类多种新发传染病，对啮齿动物、反刍动物和犬具有致病性。埃立克体属细菌侵入并在内皮细胞、白细胞中复制，或在其媒介蜱的中肠细胞和唾液腺内复制。在本综述中，我们讨论了功能研究在揭示这类细菌如何通过破坏宿主固有免疫和劫持细胞过程来利用宿主方面所提供的见解。
