Clifford P
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1338-40. doi: 10.1073/pnas.74.4.1338.
The interpretation of animal survival experiments in which disease incidence is determined at death or following sacrifice is shown to involve certain ambiguities. In particular, quantities of interest such as the expected duration of life for an animal contracting a specific disease at a specific age are found to be nonidentifiable. An example is constructed in which two populations of animals will appear similar to the experimenter but in which animals contracting a particular disease in one population may have double the life expectancy of similarly afflicted animals in the other population.
在动物存活实验中,若在动物死亡时或处死后确定疾病发病率,结果表明这种解读存在某些模糊性。特别是,诸如特定年龄感染特定疾病的动物预期寿命等感兴趣的量是无法识别的。构建了一个示例,其中两组动物群体对实验者来说可能看起来相似,但其中一组群体中感染特定疾病的动物的预期寿命可能是另一组群体中同样患病动物的两倍。