Watson G S
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1341-2. doi: 10.1073/pnas.74.4.1341.
Age incidence curves for carcinomas tend to be linear on doubly logarithmic graphs. This fact has been used to support the somatic mutation hypothesis. It is shown that this should also be expected on the epigenetic hypothesis when the reversible cellular changes are programmed to occur randomly. Such changes could be programmed differently to obtain the age incidence curves observed for other cancers, e.g., leukemias and sarcomas.
在双对数图上，癌的年龄发病率曲线往往呈线性。这一事实已被用来支持体细胞突变假说。结果表明，当可逆性细胞变化被设定为随机发生时，根据表观遗传学假说也应如此。可以对这些变化进行不同的设定，以获得针对其他癌症（如白血病和肉瘤）所观察到的年龄发病率曲线。
