Zhang Lin, Yuan Gang, Fang Yujing, Qiu Miaozhen, Lin Jianhua, Sun Jian, Yang Dajun
Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou, China.
The First Affiliated Hospital, Sun Yat-Sen University Guangzhou, China.
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11421-7. eCollection 2015.
WNT proteins are a family of secreted, cysteine-rich proteins containing 19 members. Signaling through WNT proteins is reported to be involved in carcinogenesis and cancer progression of gastrointestinal tumors, such as gastric cancer and colon cancer. The expression status of WNT6 in ESCCs and their clinico-prognostic significances remain to be elucidated. In this study, One-hundred and thirty-six patients with ESCC were explored. Paraffin-embedded tumor sections were stained with WNT6 antibody. The correlations between WNT6 expression and survival parameters were analyzed. The overall frequency of WNT6 over-expression was 50.7% (69/136) of advanced EC patients. For DMS and OS, over-expression of WNT6 remained the independent factor for worse prognosis (hazard ratio (HR), 2.425; 95% CI, 1.631-3.605; P < 0.001 for OS and HR, 2.238; 95% CI, 1.507-3.323; P < 0.001 for DMS, respectively). To conclude, our results support the concept that WNT6 may play a role in tumor progression. WNT6 over-expression inversely correlates with the poor long-term survival in ESCC patients. WNT6 can be considered as a predictor for recurrence.
WNT蛋白是一个由19个成员组成的分泌型富含半胱氨酸的蛋白家族。据报道，通过WNT蛋白进行的信号传导参与了胃肠道肿瘤（如胃癌和结肠癌）的致癌作用和癌症进展。食管鳞状细胞癌（ESCC）中WNT6的表达状态及其临床预后意义仍有待阐明。在本研究中，对136例ESCC患者进行了探究。用WNT6抗体对石蜡包埋的肿瘤切片进行染色。分析了WNT6表达与生存参数之间的相关性。晚期食管癌患者中WNT6过表达的总体频率为50.7%（69/136）。对于疾病无进展生存期（DMS）和总生存期（OS），WNT6过表达仍然是预后较差的独立因素（OS的风险比（HR）为2.425；95%置信区间（CI）为1.631 - 3.605；P < 0.001；DMS的HR为2.238；95% CI为1.507 - 3.323；P < 0.001）。总之，我们的结果支持WNT6可能在肿瘤进展中起作用这一概念。WNT6过表达与ESCC患者的长期生存率低呈负相关。WNT6可被视为复发的预测指标。
