颅内大动脉粥样硬化患者循环髓样树突状细胞前体减少。
Decrease in circulating myeloid dendritic cell precursors in patients with intracranial large artery atherosclerosis.
作者信息
Zhang Jin-Xia, Li Bing-Ling, Lin Zhong-Qiu, Zhang Ni, Peng Xiong, Gong Zhi-Hua, Long Liu-Cheng, Zhou Xuan, Xiang Ding-Cheng
机构信息
Department of Cardiovascular, Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010, China.
Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010, China.
出版信息
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11495-502. eCollection 2015.
Intracranial large artery atherosclerosis (ILAA) is a major cause of ischemic cerebrovascular disease. The aim of this study was to investigate whether the levels of circulating dendritic cell precursors (DCP) could reflect the severity of intracranial large artery atherosclerosis (ILAA). For this purpose, a series of angiography were taken to determine the severity and extent of coronary artery and intracranial large artery stenosis, and flow cytometry were taken to determine the levels of circulating mDC precursors and pDC precursors in patients with severe intracranial large artery atherosclerosis (ILAA) (n = 101) and mild intracranial large artery atherosclerosis (ILAA) (n = 123) according to the angiography. Circulating mDC precursors were lower in patients with severe intracranial large artery atherosclerosis (ILAA) than in mild intracranial large artery atherosclerosis (ILAA) (P < 0.05), but circulating pDC precursors were not significant differences (P > 0.05). According to these data, circulating mDC precursors could predict the severity of ILAA, which also could be able to reflect the severity of ILAA.
颅内大动脉粥样硬化（ILAA）是缺血性脑血管疾病的主要原因。本研究的目的是探讨循环树突状细胞前体（DCP）水平是否能反映颅内大动脉粥样硬化（ILAA）的严重程度。为此，进行了一系列血管造影以确定冠状动脉和颅内大动脉狭窄的严重程度和范围，并根据血管造影对重度颅内大动脉粥样硬化（ILAA）患者（n = 101）和轻度颅内大动脉粥样硬化（ILAA）患者（n = 123）进行流式细胞术检测，以确定循环mDC前体和pDC前体的水平。重度颅内大动脉粥样硬化（ILAA）患者的循环mDC前体低于轻度颅内大动脉粥样硬化（ILAA）患者（P < 0.05），但循环pDC前体无显著差异（P > 0.05）。根据这些数据，循环mDC前体可以预测ILAA的严重程度，也能够反映ILAA的严重程度。
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