Casella Giovanni, Bordo Bianca M, Schalling Renzo, Villanacci Vincenzo, Salemme Marianna, Di Bella Camillo, Baldini Vittorio, Bassotti Gabrio
Gastroenterology and Hepatology Unit, Medical Department, Desio Hospital, Desio, Monza e Brianza, Italy -
Minerva Gastroenterol Dietol. 2016 Jun;62(2):197-206. Epub 2015 Nov 30.
Celiac disease (CD) determines neurologic manifestations in 10% of all CD patients. We describe the most common clinical manifestations as cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression, cognitive deficiencies and other less described clinical conditions. Our aim is to perform, as more as possible, a review about the most recent update on the topics in international literature. It is important to consider clinical neurological manifestations in celiac patients and to research these conditions also in the follow-up because they may start also one year after the start of gluten free diet (GFD) as peripheral neuropathy. The association with autism is analysed and possible new association with non-celiac gluten sensitivity (NCGS) are considered.
乳糜泻(CD)在所有CD患者中有10%会出现神经学表现。我们描述了最常见的临床表现,如小脑共济失调、麸质脑病、多发性硬化症、周围神经病变、感音神经性听力损失、癫痫、头痛、抑郁、认知缺陷以及其他较少描述的临床病症。我们的目的是尽可能对国际文献中这些主题的最新进展进行综述。考虑乳糜泻患者的临床神经学表现并在随访中研究这些病症很重要,因为它们可能在无麸质饮食(GFD)开始一年后才以周围神经病变的形式出现。分析了与自闭症的关联,并考虑了与非乳糜泻麸质敏感(NCGS)可能的新关联。