The Endocrine Genetics Laboratory, Child Health and Human Development Program and Department of Pediatrics, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.
Nat Genet. 2015 Dec;47(12):1373-4. doi: 10.1038/ng.3453.
Large sample sizes, high-resolution arrays and comprehensive imputation are pushing genetic fine-mapping of complex trait loci to its limits without, in most cases, pinpointing a unique variant-gene combination. Superimposing these results on sophisticated maps of functional chromatin elements promises to break this logjam, as a new study of type 2 diabetes compellingly demonstrates.
大样本量、高分辨率阵列和全面的插补正在将复杂性状基因座的遗传精细定位推向极限，但在大多数情况下，仍无法确定独特的变异-基因组合。将这些结果叠加在功能染色质元件的复杂图谱上有望打破这一僵局，正如 2 型糖尿病的一项新研究有力地证明的那样。
