Al-Shahwan May A, Al-Othman Abdulaziz M, Al-Daghri Nasser M, Sabico Shaun B
Department of Community Health Sciences, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2015 Dec;36(12):1432-8. doi: 10.15537/smj.2015.12.12923.
To determine whether 12-month, 2000IU/day vitamin D supplementation cardiometabolically improves treatment naïve type 2 diabetes mellitus (T2DM) Saudi patients with vitamin D deficiency.
This 12-month interventional study was conducted at primary health centers in 5 different residential areas in Riyadh, Saudi Arabia between January 2013 and January 2014. Forty-five Saudi T2DM patients were enrolled. Baseline anthropometrics, glycemic, and lipid profiles were measured and repeated after 6 and 12 months. All subjects were provided with 2000IU vitamin D supplements for one year.
Vitamin D deficiency at baseline was 46.7%, 31.8% after 6 months, and 35.6% after 12 months, indicating an overall improvement in the vitamin D status in the entire cohort. Insulin and homeostatic model assessment-insulin resistance (HOMA-IR) after 12 months were significantly lower than a 6 months (p less than 0.05), but comparable to baseline values. Mean levels of triglycerides increased overtime from baseline (1.9±0.01 mmol/l) to 12 months (2.1±0.2 mmol). This modest increase in serum triglycerides was parallel to the insignificant decrease in circulating high-density lipoprotein -cholesterol levels.
Twelve-month vitamin D supplementation of 2000IU per day in a cohort of treatment naïve Saudi patients with T2DM resulted in improvement of several cardiometabolic parameters including systolic blood pressure, insulin, and HOMA-IR. Further studies that include a placebo group are suggested to reinforce findings.
确定每天补充2000国际单位维生素D持续12个月是否能在心脏代谢方面改善初治的维生素D缺乏的沙特2型糖尿病（T2DM）患者的病情。
这项为期12个月的干预性研究于2013年1月至2014年1月在沙特阿拉伯利雅得5个不同居民区的初级卫生中心进行。招募了45名沙特T2DM患者。测量了基线人体测量学、血糖和血脂指标，并在6个月和12个月后重复测量。所有受试者均接受了为期一年的2000国际单位维生素D补充剂。
基线时维生素D缺乏率为46.7%，6个月后为31.8%，12个月后为35.6%，表明整个队列的维生素D状况总体有所改善。12个月后的胰岛素和稳态模型评估-胰岛素抵抗（HOMA-IR）显著低于6个月时（p<0.05），但与基线值相当。甘油三酯的平均水平随时间从基线（1.9±0.01毫摩尔/升）增加到12个月时（2.1±0.2毫摩尔）。血清甘油三酯的这种适度增加与循环高密度脂蛋白胆固醇水平的轻微下降平行。
在一组初治的沙特T2DM患者中，每天补充2000国际单位维生素D持续12个月可改善包括收缩压、胰岛素和HOMA-IR在内的多个心脏代谢参数。建议进行包括安慰剂组的进一步研究以加强研究结果。
