Al-Daghri Nasser M, Alkharfy Khalid M, Khan Nasiruddin, Alfawaz Hanan A, Al-Ajlan Abdulrahman S, Yakout Sobhy M, Alokail Majed S
Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia, and Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia, and Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia.
Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia, and Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia, and Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Int J Vitam Nutr Res. 2014;84(1-2):27-34. doi: 10.1024/0300-9831/a000190.
The aim of our study was to evaluate the effects of vitamin D supplementation on circulating levels of magnesium and selenium in patients with type 2 diabetes mellitus (T2DM). A total of 126 adult Saudi patients (55 men and 71 women, mean age 53.6±10.7 years) with controlled T2DM were randomly recruited for the study. All subjects were given vitamin D3 tablets (2000 IU/day) for six months. Follow-up mean concentrations of serum 25-hydroxyvitamin D [25-(OH) vitamin D] significantly increased in both men (34.1±12.4 to 57.8±17.0 nmol/L) and women (35.7±13.5 to 60.1±18.5 nmol/L, p<0.001), while levels of parathyroid hormone (PTH) decreased significantly in both men (1.6±0.17 to 0.96±0.10 pmol/L, p=0.003) and women (1.6±0.17 to 1.0±0.14 pmol/L, p=0.02). In addition, there was a significant increase in serum levels of selenium and magnesium in men and women (p-values<0.001 and 0.04, respectively) after follow-up. In women, a significant correlation was observed between delta change (variables at six months-variable at baseline) of serum magnesium versus high-density lipoprotein (HDL)-cholesterol (r=0.36, p=0.006) and fasting glucose (r=-0.33, p=0.01). In men, there was a significant correlation between serum selenium and triglycerides (r=0.32, p=0.04). Vitamin D supplementation improves serum concentrations of magnesium and selenium in a gender-dependent manner, which in turn could affect several cardiometabolic parameters such as glucose and lipids.
我们研究的目的是评估补充维生素D对2型糖尿病（T2DM）患者循环中镁和硒水平的影响。总共随机招募了126例T2DM得到控制的沙特成年患者（55名男性和71名女性，平均年龄53.6±10.7岁）参与该研究。所有受试者均服用维生素D3片（2000 IU/天），持续6个月。随访时，男性（从34.1±12.4至57.8±17.0 nmol/L）和女性（从35.7±13.5至60.1±18.5 nmol/L，p<0.001）血清25-羟维生素D [25-(OH)维生素D]的平均浓度均显著升高，而甲状旁腺激素（PTH）水平在男性（从1.6±0.17至0.96±0.10 pmol/L，p=0.003）和女性（从1.6±0.17至1.0±0.14 pmol/L，p=0.02）中均显著降低。此外，随访后男性和女性的血清硒和镁水平均显著升高（p值分别<0.001和0.04）。在女性中，血清镁的变化量（6个月时的变量 - 基线时的变量）与高密度脂蛋白（HDL）胆固醇（r=0.36，p=0.006）和空腹血糖（r=-0.33，p=0.01）之间存在显著相关性。在男性中，血清硒与甘油三酯之间存在显著相关性（r=0.32，p=0.04）。补充维生素D以性别依赖的方式改善血清镁和硒浓度，这反过来可能会影响一些心脏代谢参数，如血糖和血脂。
