自然灾害后5岁以下儿童的营养干预措施：一项系统评价方案

Nutrition interventions for children aged less than 5 years following natural disasters: a systematic review protocol.

作者信息

Pradhan Pranil Man Singh, Dhital Rolina, Subhani Huma

机构信息

Department of Community Health Sciences, Patan Academy of Health Sciences, Lalitpur, Nepal.

出版信息

BMJ Open. 2015 Nov 30;5(11):e009525. doi: 10.1136/bmjopen-2015-009525.

DOI:10.1136/bmjopen-2015-009525

PMID:26621520

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4679839/

Abstract

INTRODUCTION

Malnutrition among children is a serious public health problem in the aftermath of any natural disaster. We will review the various nutrition interventions for children aged <5 years in countries where natural disasters occurred and analyse the effect on nutrition-related outcomes.

METHODS AND ANALYSIS

We will conduct a systematic review on nutrition intervention studies following natural disasters that were published between January 2000 and December 2015. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Cochrane Risk of Bias (RoB) tool will be used for randomised controlled trials and Risk of Bias Assessment for Non-Randomized Studies (RoBANS) will be used for non-randomised studies. The quality of evidence will be assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. If sufficient data are available, we will conduct meta-analyses to establish the relationship between nutrition interventions and nutrition outcome indicators. All statistical analyses will be performed using Review Manager (Rev Man) V.5.3 for Windows. Heterogeneity of the data will be tested using the standard χ(2) test. A fixed-effect model will be used for the studies with high heterogeneity (p value>0.10, I(2)≤50%). For dichotomous and continuous data, relative risk (RR) and mean difference with 95% CI will be used respectively. Subgroup analysis will be performed for studies with low heterogeneity (p value ≤0.10). We will use Z score with the level of significance set at p value <0.05 to test the total effect. Funnel plots will be used to detect publication bias.

ETHICS AND DISSEMINATION

As primary data will not be collected, formal ethical approval will not be required. The results will be disseminated by publication in peer-reviewed journals, conference presentations and the media.

REGISTRATION DETAILS

International Prospective Register for Systematic Reviews (PROSPERO) number CRD42015023243 was registered on 1 June 2015.

摘要

引言

在任何自然灾害之后，儿童营养不良都是一个严重的公共卫生问题。我们将回顾自然灾害发生国家中针对5岁以下儿童的各种营养干预措施，并分析其对营养相关结局的影响。

方法与分析

我们将对2000年1月至2015年12月期间发表的关于自然灾害后营养干预研究进行系统综述。研究选择将遵循系统评价和Meta分析的首选报告项目（PRISMA）指南。Cochrane偏倚风险（RoB）工具将用于随机对照试验，非随机研究的偏倚风险评估（RoBANS）将用于非随机研究。证据质量将使用推荐分级评估、制定和评价（GRADE）指南进行评估。如果有足够的数据，我们将进行Meta分析以确定营养干预与营养结局指标之间的关系。所有统计分析将使用适用于Windows的Review Manager（Rev Man）V.5.3进行。数据的异质性将使用标准χ(2)检验进行测试。对于异质性高的研究（p值>0.10，I(2)≤50%）将使用固定效应模型。对于二分法和连续数据，将分别使用相对风险（RR）和95%置信区间的平均差。对于异质性低的研究（p值≤0.10）将进行亚组分析。我们将使用显著性水平设定为p值<0.05的Z分数来检验总体效应。漏斗图将用于检测发表偏倚。