Schnur P, Martinez R A
Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.
Pharmacol Biochem Behav. 1989 Mar;32(3):589-94. doi: 10.1016/0091-3057(89)90002-6.
Eight experiments were conducted to investigate the effects of apomorphine, a dopaminergic agonist, and of morphine, an opiate, on stereotyped behavior in the hamster. Animals were observed at two minute intervals for one hour and incidents of stereotyped gnawing, licking and sniffing were recorded using a time-sampling method. Both morphine and apomorphine produced dose-related increases in stereotyped gnawing. A low dose of the opiate antagonist, naloxone (0.4 mg/kg), blocked morphine-induced gnawing but neither that dose nor higher doses of naloxone (1, 4 and 10 mg/kg) blocked apomorphine-induced gnawing. A low dose of the dopaminergic antagonist, haloperidol (0.05 mg/kg), blocked apomorphine-induced gnawing but did not block morphine-induced gnawing. Further experiments indicated that morphine administration did not sensitize, or influence in any way, subsequent apomorphine-induced stereotyped behavior.
进行了八项实验，以研究多巴胺能激动剂阿扑吗啡和阿片类药物吗啡对仓鼠刻板行为的影响。每隔两分钟观察动物一小时，并使用时间抽样方法记录刻板啃咬、舔舐和嗅闻的事件。吗啡和阿扑吗啡均使刻板啃咬行为呈剂量相关增加。低剂量的阿片拮抗剂纳洛酮（0.4毫克/千克）可阻断吗啡诱导的啃咬行为，但该剂量以及更高剂量的纳洛酮（1、4和10毫克/千克）均不能阻断阿扑吗啡诱导的啃咬行为。低剂量的多巴胺能拮抗剂氟哌啶醇（0.05毫克/千克）可阻断阿扑吗啡诱导的啃咬行为，但不能阻断吗啡诱导的啃咬行为。进一步的实验表明，给予吗啡不会使随后阿扑吗啡诱导的刻板行为敏感化，或以任何方式影响该行为。
