阿扑吗啡诱导的刻板啃咬行为的定量分析。
A quantitative analysis of stereotyped gnawing induced by apomorphine.
作者信息
Redgrave P, Dean P, Lewis G
出版信息
Pharmacol Biochem Behav. 1982 Nov;17(5):873-6. doi: 10.1016/0091-3057(82)90464-6.
An apparatus was designed and constructed to enable a quantitative analysis of the stereotyped gnawing produced by the dopamine agonist apomorphine. Using this apparatus it was discovered that increasing the subcutaneous dose of apomorphine increased (1) the number of animals that gnawed, and (2) the duration of gnawing in those animals that gnawed at all doses. Other aspects of apomorphine-induced gnawing, in particular the latency to respond and the frequency and duration of individual gnaws, were relatively unaffected. Likely properties of the system responsible for the organization of sterotyped gnawing are discussed.
设计并构建了一种仪器，用于对多巴胺激动剂阿扑吗啡引起的刻板啃咬行为进行定量分析。使用该仪器发现，增加阿扑吗啡的皮下给药剂量会增加：（1）啃咬的动物数量，以及（2）在所有剂量下啃咬的动物的啃咬持续时间。阿扑吗啡诱导的啃咬行为的其他方面，特别是反应潜伏期以及单个啃咬动作的频率和持续时间，相对未受影响。本文讨论了负责刻板啃咬行为组织的系统可能具有的特性。
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