Margolin D I, Moon B H
J Neurol Sci. 1979 Sep;43(1):13-7. doi: 10.1016/0022-510x(79)90069-8.
The specific opiate antagonist, naloxone, inhibits the in vivo and in vitro activity of the endogenous opiate compounds which have heretofore been identified. In this study systemic naloxone administration successfully blocked the production of stereotyped behavior induced by the direct dopamine agonist apomorphine. This implies that the endogenous opiates contribute to the production of stereotyped behavior initiated by dopaminergic stimulation and that endogenous opiates may function as central neurotransmitters with dopaminergic activity.
特异性阿片拮抗剂纳洛酮可抑制迄今已被鉴定出的内源性阿片化合物的体内和体外活性。在本研究中，全身性给予纳洛酮成功阻断了直接多巴胺激动剂阿扑吗啡诱导的刻板行为的产生。这意味着内源性阿片类物质有助于由多巴胺能刺激引发的刻板行为的产生，并且内源性阿片类物质可能作为具有多巴胺能活性的中枢神经递质发挥作用。
