Sýkora P, Foltýnova Z, Smitálova K
Institute of Molecular and Subcellular Biology, Comenius University, Bratislava, Czechoslovakia.
Plasmid. 1989 Mar;21(2):85-98. doi: 10.1016/0147-619x(89)90052-8.
A simple mathematical model of drug-induced plasmid elimination (curing) considering density-dependent growth rates and plasmid transfers is presented. It describes nonlinear population dynamics of conjugative plasmids during in vitro curing experiments in batch culture. The model was tested on kinetics of acridine orange curing of F'lac plasmid. Effects of density dependence, plasmid elimination, selection for plasmidless segregants, conjugation, initial and maximal population density, and postsegregational killing on curing kinetics are simulated and discussed.
提出了一个考虑密度依赖生长速率和质粒转移的药物诱导质粒消除（治愈）的简单数学模型。它描述了分批培养体外治愈实验过程中接合质粒的非线性种群动态。该模型在F'lac质粒吖啶橙治愈动力学上进行了测试。模拟并讨论了密度依赖性、质粒消除、无质粒分离株的选择、接合、初始和最大种群密度以及分离后杀伤对治愈动力学的影响。
