含三联基序蛋白29作为非小细胞肺癌的一种新型生物标志物
Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer.
作者信息
Song Xiaoming, Fu Chunhai, Yang Xudong, Sun Dongfeng, Zhang Xianqi, Zhang Jiandong
机构信息
Department of Thoracic Surgery, Shandong Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China.
Department of Thoracic Surgery, Hospital of Shandong Aluminum Corporation, Zibo, Shandong 255069, P.R. China.
出版信息
Oncol Lett. 2015 Oct;10(4):2283-2288. doi: 10.3892/ol.2015.3623. Epub 2015 Aug 19.
Tripartite motif-containing 29 (TRIM29) is a member of the tripartite motif (TRIM) protein family. TRIM29 has been reported to be deregulated in a number of cancer types, suggesting the oncogenic function of TRIM29. However, its clinical significance in non-small cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the TRIM29 expression status was investigated by immunohistochemical analysis in paraffin-embedded specimens obtained from 320 patients with surgically resected NSCLC, treated between 2000 and 2007. High TRIM29 expression was significantly associated with smoking (P=0.012), T stage (P=0.015) and M stage (P=0.003). Furthermore, elevated TRIM29 expression level was correlated with reduced overall (OS) and disease-free survival. In addition, high TRIM29 expression was an independent prognostic factor for OS [P=0.003, hazard ratio (HR)=2.102, 95% confidence interval (CI), 1.069-3.193]. In conclusion, these results suggest that TRIM29 may be a useful prognostic marker in NSCLC patients and a potential molecular target for NSCLC treatment.
含三联基序的蛋白29（TRIM29）是三联基序（TRIM）蛋白家族的成员。据报道，TRIM29在多种癌症类型中表达失调，提示其具有致癌功能。然而，其在非小细胞肺癌（NSCLC）中的临床意义尚未完全阐明。在本研究中，通过免疫组织化学分析对2000年至2007年间接受手术切除的320例NSCLC患者石蜡包埋标本中的TRIM29表达状态进行了研究。TRIM29高表达与吸烟（P=0.012）、T分期（P=0.015）和M分期（P=0.003）显著相关。此外，TRIM29表达水平升高与总生存期（OS）和无病生存期缩短相关。此外，TRIM29高表达是OS的独立预后因素[P=0.003，风险比（HR）=2.102，95%置信区间（CI），1.069-3.193]。总之，这些结果表明，TRIM29可能是NSCLC患者有用的预后标志物，也是NSCLC治疗的潜在分子靶点。
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