Lippi I, Perondi F, Ross S J, Marchetti V, Lubas G, Guidi G
UC Veterinary Medical Center San Diego 10435 Sorrento Valley Rd, Suite 101, San Diego, CA 92121, USA.
Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese lato monte, 56122 San Piero a Grado (PI), Italy.
Open Vet J. 2015;5(2):108-12. Epub 2015 Aug 7.
A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma. The dog received three double filtration plasmapheresis treatments on day 0, 7 and 22 after presentation. A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment. These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome. The present study reported for the first time the use of double filtration plasmapheresis to reduce clinical signs of hyperviscosity syndrome in a dog with multiple myeloma.
一只12岁、体重38公斤的杂种未绝育雄性犬，出现了持续20天的临床症状，与多发性骨髓瘤继发的高粘滞综合征相符。该犬在就诊后的第0天、第7天和第22天接受了三次双重滤过血浆置换治疗。每次治疗后，血清总蛋白、α-2球蛋白和γ球蛋白均显著降低（p<0.05）。这些降低伴随着高粘滞综合征临床症状的完全缓解，尽管是暂时的。本研究首次报道了使用双重滤过血浆置换来减轻一只患有多发性骨髓瘤犬的高粘滞综合征临床症状。
