Thode J, Juul-Jørgensen B, Bhatia H M, Kjaerulf-Nielsen M, Bartels P D, Fogh-Andersen N, Siggaard-Andersen O
Department of Clinical Chemistry, Herlev University Hospital, Denmark.
Scand J Clin Lab Invest. 1989 May;49(3):217-23.
The correlations between serum ionized calcium, serum total calcium, total calcium corrected for albumin and calculated ionized calcium were investigated in a prospective multicentre investigation of 1213 patients suspected of having calcium metabolic disease. Diagnostic discordance between serum total calcium and measured ionized calcium was found in 31% of the patients. With the calculation of albumin-corrected total calcium or calculated ionized calcium the discordance decreased to 17.9%. The diagnostic discordance which could be ascribed to the analytical imprecision (CV = 1.5%) amounted to only 6.7%. Although we found highly significant correlations between the parameters, a considerable scatter around the regression line made prediction of ionized calcium from albumin-corrected total calcium unreliable in many patients.
在一项对1213例疑似钙代谢疾病患者的前瞻性多中心研究中，对血清离子钙、血清总钙、白蛋白校正总钙和计算离子钙之间的相关性进行了研究。31%的患者血清总钙与测量的离子钙之间存在诊断不一致。通过计算白蛋白校正总钙或计算离子钙，不一致率降至17.9%。可归因于分析不精密度（CV = 1.5%）的诊断不一致仅为6.7%。尽管我们发现这些参数之间存在高度显著的相关性，但回归线周围仍有相当大的离散度，使得许多患者从白蛋白校正总钙预测离子钙并不可靠。
