Tomita Masaki, Ayabe Takanori, Chosa Eiichi, Nakamura Kunihide
Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan E-mail :
Asian Pac J Cancer Prev. 2015;16(17):7809-12. doi: 10.7314/apjcp.2015.16.17.7809.
In non-small cell lung cancer (NSCLC) patients with preoperative high serum carcinoembryonic antigen (CEA) level, patients with a persistently high serum CEA level after surgery have been reported to have a poor prognosis. In addition, in other cancers, the post/preoperative serum CEA ratio has been reported as a useful parameter.
We enrolled 123 NSCLC patients with preoperative high CEA levels (≥ 5 ng/mL) who underwent curative surgery between 2004 and 2011. Prognostic significance of postoperative serum CEA level and the CEA ratio was examined.
The 5-year survival of patients with persistently high serum CEA level after surgery was poor. On the other hand, patients with normal postoperative serum CEA levels had significant favorable prognosis. The patients with CEA ratio>1 had poor prognosis, however the number was only 7 (5.7%). The 5-year survival rates of patients with other subgroup based on the CEA ratio (0.5 ≥ CEA ratio and 0.5 ≤ CEA ratio ≤ 1) was similar. Multivariate analysis revealed prognostic significance for the postoperative serum CEA level but not the CEA ratio.
For NSCLC patients with preoperative high serum CEA level, their postoperative serum CEA levels is a more significant prognostic factor than the post/preoperative serum CEA ratio.
在术前血清癌胚抗原（CEA）水平较高的非小细胞肺癌（NSCLC）患者中，据报道术后血清CEA水平持续较高的患者预后较差。此外，在其他癌症中，术前/术后血清CEA比值已被报道为一个有用的参数。
我们纳入了2004年至2011年间接受根治性手术的123例术前CEA水平较高（≥5 ng/mL）的NSCLC患者。研究了术后血清CEA水平和CEA比值的预后意义。
术后血清CEA水平持续较高的患者5年生存率较差。另一方面，术后血清CEA水平正常的患者预后明显较好。CEA比值>1的患者预后较差，但数量仅为7例（5.7%）。基于CEA比值的其他亚组（0.5≥CEA比值且0.5≤CEA比值≤1）患者的5年生存率相似。多因素分析显示术后血清CEA水平具有预后意义，而CEA比值则无。
对于术前血清CEA水平较高的NSCLC患者，其术后血清CEA水平比术前/术后血清CEA比值是更重要的预后因素。
