Belcaro G, Christopoulos D, Nicolaides A N
Vasa. 1989;18(2):136-9.
It has been demonstrated that skin blood flow of postphlebitic limbs is increased. Also the venoarteriolar response (VAR), i.e. precapillary vasoconstriction present in normal limbs on standing up, is reduced in limbs with venous insufficiency, resulting in capillary hypertension. The supine skin resting flow (SF) and the skin flow on standing (SF) have been measured with laser-Doppler in 30 normal lower limbs and 70 postphlebitic limbs with ambulatory venous pressure greater than 65 mmHg; also, the rate of ankle swelling (RAS) has been measured with strain-gauge plethysmography. The VAR was derived from VAR = 100* (RF-SF)/RF. The reduction of VAR and the increase in SF, which has been demonstrated in the postphlebitic limbs, correlated well with the rate of ankle swelling (RAS). The measurements of SF, VAR and RAS evaluate objectively the degree of impairment of the microcirculation because of severe venous disease. They offer the possibility to study the natural history and the effect of treatment of venous hypertensive microangiopathy.
已经证实，静脉炎后肢体的皮肤血流量会增加。此外，静脉小动脉反应（VAR），即正常肢体站立时出现的毛细血管前血管收缩，在静脉功能不全的肢体中会减弱，从而导致毛细血管高血压。在30条正常下肢和70条动态静脉压大于65 mmHg的静脉炎后肢体中，使用激光多普勒测量了仰卧位皮肤静息血流量（SF）和站立时的皮肤血流量（SF）；此外，还使用应变片体积描记法测量了踝部肿胀率（RAS）。VAR由VAR = 100×（RF - SF）/RF得出。在静脉炎后肢体中已证实的VAR降低和SF增加与踝部肿胀率（RAS）密切相关。SF、VAR和RAS的测量客观地评估了严重静脉疾病导致的微循环受损程度。它们为研究静脉性高血压微血管病的自然病程和治疗效果提供了可能性。
