Lotze W
Frauenklinik, Bezirkskrankenhauses Meiningen.
Zentralbl Gynakol. 1989;111(9):559-66.
Continuous increase of incidence of breast cancer in the last decades lead to a maximum position concerning morbidity and mortality in malignant diseases of women. Fatality of the disease couldn't be decreased, despite improved methods of health education, diagnostics and therapy so that further on early detection is of particular importance. By extensive clinical and epidemiological studies multifactorial genesis of breast cancer and the influence of different risk symptoms could be secured. The etiologically significant endo- and exogenic components have such a differentiated and complex effect that formation of risk groups is still in discussion. Considering special endocrine, genetic and environmental factors it is possible to define groups of patients whose morbidity risk is much increased. Registration and prophylactic care of such risk groups seems to be of advantage and could enable an improvement of early detection rate.
在过去几十年中，乳腺癌发病率持续上升，在女性恶性疾病的发病率和死亡率方面占据首位。尽管健康教育、诊断和治疗方法有所改进，但该疾病的死亡率并未降低，因此早期发现仍然尤为重要。通过广泛的临床和流行病学研究，乳腺癌的多因素成因以及不同风险症状的影响得以确定。具有病因学意义的内源性和外源性因素具有如此分化和复杂的作用，以至于风险群体的形成仍在讨论之中。考虑到特殊的内分泌、遗传和环境因素，可以确定发病风险大幅增加的患者群体。对此类风险群体进行登记和预防性护理似乎具有优势，并且能够提高早期发现率。
