Worm A M, Pedersen-Bjergaard J
Scand J Haematol. 1977 Apr;18(4):288-91. doi: 10.1111/j.1600-0609.1977.tb01198.x.
The interval from diagnosis of chronic myelocytic leukaemia (CML) to onset of blastic transformation (BT) can vary from days to several years. This blastic phase of CML is indistinguishable from acute myelocytic leukaemia (AML), both clinically and morphologically. The Ph1 chromosome has occasionally been demonstrated in acute leukaemia and it has been suggested that these cases may represent CML presenting in BT. 2 such patients are reported, in 1 of whom the characteristics after treatment further confirmed the diagnosis of CML. Differentiation between CML presenting in BT and AML has both prognostic and therapeutic value. For this reason it is recommended that cytogenetic screening for the Ph1 chromosome should be included in the initial examination of patients with acute leukaemia.
从慢性粒细胞白血病（CML）诊断到急变期（BT）开始的时间间隔可能从数天到数年不等。CML的急变期在临床和形态学上与急性髓细胞白血病（AML）无法区分。Ph1染色体偶尔在急性白血病中被发现，有人提出这些病例可能代表处于急变期的CML。本文报告了2例此类患者，其中1例患者治疗后的特征进一步证实了CML的诊断。区分处于急变期的CML和AML具有预后和治疗价值。因此，建议在急性白血病患者的初始检查中进行Ph1染色体的细胞遗传学筛查。
