以急变期表现的慢性粒细胞白血病及其与45，XO Ph1核型的关联。

Chronic myelogenous leukemia presenting in the blastic phase and its association with a 45 XO Ph1 karyotype.

作者信息

Nigam R, Dosik H

出版信息

Blood. 1976 Feb;47(2):223-7.

Abstract

A 58-yr-old male patient presented in the blastic phase of chronic myelogenous leukemia (CML). Cytogenetic studies revealed a 45 XO Ph1 chromosome pattern in bone marrow cells during a short remission and again in the blastic phase of the disease. The patient expired 8 mo following diagnosis. The blastic phase of CML can stimulate acute myelogenous leukemia (AML) clinically and hematologically; CML can be differentiated by the presence of the Ph1 chromosome and the stigmata of CML. Absence of the Y chromosome from the bone marrow in CML is a recently described finding. Previous reports indicating the prevention of the blastic phase in patients with this karyotype could not be confirmed by our or other recently reported cases.

摘要

一名58岁男性患者处于慢性髓性白血病（CML）的急变期。细胞遗传学研究显示，在疾病短期缓解期以及急变期时，骨髓细胞中存在45,XO Ph1染色体模式。该患者在诊断后8个月死亡。CML急变期在临床和血液学上可类似急性髓性白血病（AML）；CML可通过Ph1染色体的存在以及CML的特征来鉴别。CML患者骨髓中Y染色体缺失是最近报道的一个发现。之前有关此核型患者可预防急变期的报道，我们的病例或其他近期报道的病例均无法证实。