Pearl Mizrahi Sivan, Sandler Oded, Lande-Diner Laura, Balaban Nathalie Q, Simon Itamar
Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem, Israel.
Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
Bioessays. 2016 Jan;38(1):8-13. doi: 10.1002/bies.201500113. Epub 2015 Dec 2.
We describe a recent approach for distinguishing between stochastic and deterministic sources of variability, focusing on the mammalian cell cycle. Variability between cells is often attributed to stochastic noise, although it may be generated by deterministic components. Interestingly, lineage information can be used to distinguish between variability and determinism. Analysis of correlations within a lineage of the mammalian cell cycle duration revealed its deterministic nature. Here, we discuss the sources of such variability and the possibility that the underlying deterministic process is due to the circadian clock. Finally, we discuss the "kicked cell cycle" model and its implication on the study of the cell cycle in healthy and cancerous tissues.
我们描述了一种区分变异性随机源和确定性源的最新方法，重点关注哺乳动物细胞周期。细胞间的变异性通常归因于随机噪声，尽管它可能由确定性成分产生。有趣的是，谱系信息可用于区分变异性和确定性。对哺乳动物细胞周期持续时间谱系内相关性的分析揭示了其确定性本质。在此，我们讨论这种变异性的来源以及潜在确定性过程归因于生物钟的可能性。最后，我们讨论“受激细胞周期”模型及其对健康组织和癌组织中细胞周期研究的意义。
