Yao Juan, Shaw Chris, Lai C J, Rong John, Wang Jian, Liu Wenya
The Imaging Center, The First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, China.
MD Anderson Cancer Center, The University of Texas TX 77030, USA.
Int J Clin Exp Med. 2015 Sep 15;8(9):15206-13. eCollection 2015.
To assess the ability of cone beam CT (CBCT) in determining the breast cancer margin using, to compare the results with mammography and specimen radiography, and to explore the clinical potential of CBCT for breast imaging.
Specimens of 46 breast cancer patients were imaged by using a prototype CBCT system. Each patient underwent mammography, CBCT and X-ray of breast surgical specimen within 6 months. Images of mammography, breast surgical specimen radiography and CBCT were evaluated by an experienced radiologist. Indicators, such as: morphology, glitch, density, invasion, structural distortion and calcification, were observed.
There was no significant difference of the calcification, glitch and morphology among three methods. However, there was significant difference in indicators of breast tumor invasion among three methods. There was statistical significance in detecting invasions of breast cancer cells in peripheral tissues among three methods.
CBCT shows no superiority over mammography and specimen radiography in determining tumor's outline and detecting calcification. On the other hand, CBCT demonstrates its advantage in determining the 3 dimensional position of a lesion which could be a potential clinical application in future practices of breast imaging.
评估锥形束CT（CBCT）在确定乳腺癌切缘方面的能力，将结果与乳腺X线摄影和标本射线摄影进行比较，并探索CBCT在乳腺成像中的临床潜力。
使用原型CBCT系统对46例乳腺癌患者的标本进行成像。每位患者在6个月内接受了乳腺X线摄影、CBCT和乳腺手术标本的X线检查。由一位经验丰富的放射科医生对乳腺X线摄影、乳腺手术标本射线摄影和CBCT的图像进行评估。观察钙化、毛刺、密度、浸润、结构扭曲和钙化等指标。
三种方法在钙化、毛刺和形态方面无显著差异。然而，三种方法在乳腺肿瘤浸润指标上存在显著差异。三种方法在检测外周组织中乳腺癌细胞浸润方面具有统计学意义。
在确定肿瘤轮廓和检测钙化方面，CBCT并不优于乳腺X线摄影和标本射线摄影。另一方面，CBCT在确定病变的三维位置方面显示出其优势，这可能是未来乳腺成像实践中的一种潜在临床应用。
