Xu Bing, Yang Jia, Kang Fang, Li Juan
School of Medicine, Shandong University Jinan, Shandong, China ; Department of Anesthesiology, Anhui Provincial Hospital Hefei, China.
Department of Anesthesiology, Anhui Provincial Hospital Hefei, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):16694-8. eCollection 2015.
Vascular cognitive impairment, caused by vascular injury and inflammation, affects brain function. Present treatment for vascular injury primarily relies on combination therapy of surgery with anesthesia. In this study, we sought to determine the effects of anesthetics, sevoflurane and fentanyl, on long-term cognitive function in brain tissue of rats, and potential correlations with inflammatory factors such as VEGF, IL-1β, TNF-α. We used shuttle box and water maze tests to study the cognitive function of Wistar rats. The results demonstrated that rats treated with sevoflurane or fentanyl performed less shock times and more active escape times compared with rats model undergoing vascular cognitive impairment. Treatment of anesthetics also shortened the periods of learning and memory incubation, suggesting a protective role in cognitive function. In addition, our results unraveled a reducing expression of TNF-α and IL-1β but an increasing level of VEGF in head tissues of rats implemented with anesthetics. These findings underscore the improving role of sevoflurane and fentanyl in the recovery of vascular cognitive impairment rats as well as the cognitive function in rats, by regulating the expression of inflammatory factors.
由血管损伤和炎症引起的血管性认知障碍会影响脑功能。目前针对血管损伤的治疗主要依赖于手术与麻醉的联合治疗。在本研究中，我们试图确定麻醉剂七氟醚和芬太尼对大鼠脑组织长期认知功能的影响，以及与血管内皮生长因子（VEGF）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）等炎症因子的潜在相关性。我们使用穿梭箱和水迷宫试验来研究Wistar大鼠的认知功能。结果表明，与经历血管性认知障碍的大鼠模型相比，接受七氟醚或芬太尼治疗的大鼠电击次数减少，主动逃避次数增加。麻醉剂治疗还缩短了学习和记忆潜伏期，表明对认知功能具有保护作用。此外，我们的结果揭示了在接受麻醉剂处理的大鼠头部组织中，TNF-α和IL-1β的表达降低，但VEGF水平升高。这些发现强调了七氟醚和芬太尼通过调节炎症因子的表达，在血管性认知障碍大鼠的恢复以及大鼠认知功能改善方面所起的作用。
