Donate-Correa Javier, Martín-Núñez Ernesto, Mora-Fernández Carmen, Muros-de-Fuentes Mercedes, Pérez-Delgado Nayra, Navarro-González Juan F
Javier Donate-Correa, Ernesto Martín-Núñez, Carmen Mora-Fernández, Juan F Navarro-González, Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain.
World J Biol Chem. 2015 Nov 26;6(4):351-7. doi: 10.4331/wjbc.v6.i4.351.
Protein Klotho, beyond its role as a regulator of the phosphatemia, is also involved in the maintaining of the cardiovascular health, being associated its alterations with the development of cardiovascular damage and increased morbi-mortality. For all this, nowadays Klotho is the subject of a thorough research which is focused on uncover its intimate mechanisms of action, and in analyzing the utility of its modulation as a potential strategy with clinical applicability. Molecular mechanisms of Klotho are not well understood but an emerging research area links Klotho deficiency with vascular pathology. Changes in this protein have been associated with cardiovascular-related complications like inflammation, vascular calcification, and endothelial dysfunction. All this is particularly relevant if considering the recent discovery of Klotho expression in vascular tissue.
蛋白质α-klotho，除了作为血磷调节剂的作用外，还参与维持心血管健康，其改变与心血管损伤的发生和死亡率增加有关。基于此，如今α-klotho是深入研究的对象，该研究专注于揭示其确切作用机制，并分析调节α-klotho作为具有临床适用性的潜在策略的效用。α-klotho的分子机制尚未完全了解，但一个新兴的研究领域将α-klotho缺乏与血管病变联系起来。这种蛋白质的变化与心血管相关并发症如炎症、血管钙化和内皮功能障碍有关。如果考虑到最近在血管组织中发现α-klotho表达，所有这些都特别相关。
