Burkert Seth C, Star Alexander
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Curr Protoc Chem Biol. 2015 Dec 2;7(4):249-262. doi: 10.1002/9780470559277.ch150093.
Carbon nanomaterials have been proposed as effective drug delivery devices; however their perceived biopersistence and toxicological profile may hinder their applications in medical therapeutics. Nitrogen doping of carbon nanotubes results in a unique "stacked-cup" structure, with cups held together through van der Waals forces. Disrupting these weak interactions yields individual and short-stacked nanocups that can subsequently be corked with gold nanoparticles, resulting in sealed containers for delivery of cargo. Peroxidase-catalyzed reactions can effectively uncork these containers, followed by complete degradation of the graphitic capsule, resulting in effective release of therapeutic cargo while minimizing harmful side effects. The protocols reported herein describe the synthesis of stacked nitrogen-doped carbon nanotube cups followed by effective separation into individual cups and gold nanoparticle cork formation resulting in loaded and sealed containers.
碳纳米材料已被提议作为有效的药物递送装置；然而，它们被认为的生物持久性和毒理学特征可能会阻碍其在医学治疗中的应用。碳纳米管的氮掺杂会产生独特的“堆叠杯”结构，杯状物通过范德华力聚集在一起。破坏这些弱相互作用会产生单个的和短堆叠的纳米杯，随后可以用金纳米颗粒将其封闭，从而形成用于递送货物的密封容器。过氧化物酶催化反应可以有效地打开这些容器，随后石墨胶囊完全降解，从而在将有害副作用降至最低的同时有效释放治疗性货物。本文报道的方案描述了堆叠氮掺杂碳纳米管杯的合成，随后有效地分离成单个杯并形成金纳米颗粒塞，从而得到装载并密封的容器。
