Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Inflammation. 2010 Aug;33(4):276-80. doi: 10.1007/s10753-010-9182-7.
Carbon nanotubes (CNTs) have been one of the most extensively researched and developed nanomaterials. However, little concern has been placed on their safety. The biological effects of CNTs are believed to differ relative to size and shape. Thus, the relationship between the characteristics of CNTs and their safety needs to be evaluated. In this study, we examined the biological effects of different-sized multi-walled CNTs (MWCNTs) and single-walled CNTs (SWCNTs). Long and thick MWCNTs induced the strongest DNA damage while similar SWCNTs caused little effect. Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice. These results indicate that long and thick MWCNT, but not short and thin MWCNT, cause DNA damage and severe inflammatory effects. These findings might provide useful information for constructing novel CNTs with safety.
碳纳米管（CNTs）是研究和开发最多的纳米材料之一。然而，人们对其安全性的关注甚少。CNTs 的生物效应据信与其大小和形状有关。因此，需要评估 CNT 的特性与其安全性之间的关系。在这项研究中，我们研究了不同大小的多壁碳纳米管（MWCNTs）和单壁碳纳米管（SWCNTs）的生物学效应。长而粗的 MWCNTs 诱导最强的 DNA 损伤，而类似的 SWCNTs 则几乎没有影响。比较各种类型 CNTs 的炎症反应发现，腹腔内给予长而粗的 MWCNTs 会增加小鼠腹腔灌洗液中的总细胞数。这些结果表明，长而粗的 MWCNT 而不是短而细的 MWCNT 会导致 DNA 损伤和严重的炎症反应。这些发现可能为构建具有安全性的新型 CNTs 提供有用信息。
