脑间质空间中的物质运输可由神经元兴奋调节。
Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation.
作者信息
Shi Chunyan, Lei Yiming, Han Hongbin, Zuo Long, Yan Junhao, He Qingyuan, Yuan Lan, Liu Huipo, Xu Ge, Xu Weiguo
机构信息
Department of Radiology, Peking University Third Hospital, Peking University, Beijing 100191, China.
Beijing Key Lab. of Magnetic Resonance Imaging Technology, Beijing 100191, China.
出版信息
Sci Rep. 2015 Dec 3;5:17673. doi: 10.1038/srep17673.
Abstract
The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation.
摘要
间质空间（ISS）中的物质运输对于维持脑内稳态至关重要，然而其与神经元活动的联系仍不清楚。在此，我们报告神经元兴奋后ISS中物质运输显著减少。使用基于示踪剂的方法，间质液（ISF）中的水分子在磁共振（MR）成像中能够被特异性可视化。我们首先观察了大鼠丘脑和尾状核中ISF的流动。然后使用疼痛刺激模型调节ISF流动。我们证明，丘脑神经元活动后ISF流动显著减慢。这种ISF流动的减少持续数小时，且未伴随向ISS的缓慢扩散。该观察结果表明，物质向ISS的运输可通过选择性外部刺激进行调节。
相似文献
1
Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation.
Sci Rep. 2015 Dec 3;5:17673. doi: 10.1038/srep17673.
2
An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain.
Sci China Life Sci. 2012 Sep;55(9):782-7. doi: 10.1007/s11427-012-4361-4. Epub 2012 Sep 27.
3
[Drainage characteristic of the brain interstitial fluid detected by using fluorescence and magnetic tracer method].
Beijing Da Xue Xue Bao Yi Xue Ban. 2017 Apr 18;49(2):303-309.
4
Propofol rather than Isoflurane Accelerates the Interstitial Fluid Drainage in the Deep Rat Brain.
Int J Med Sci. 2021 Jan 1;18(3):652-659. doi: 10.7150/ijms.54320. eCollection 2021.
5
Bloodletting at Jing-well points decreases interstitial fluid flow in the thalamus of rats.
J Tradit Chin Med. 2016 Feb;36(1):107-12. doi: 10.1016/s0254-6272(16)30016-4.
6
The Effect of Aquaporin-4 Knockout on Interstitial Fluid Flow and the Structure of the Extracellular Space in the Deep Brain.
Aging Dis. 2018 Oct 1;9(5):808-816. doi: 10.14336/AD.2017.1115. eCollection 2018 Oct.
7
[Discovery of a new division system in brain and the regionalized drainage route of brain interstitial fluid].
Beijing Da Xue Xue Bao Yi Xue Ban. 2019 Jun 18;51(3):397-401. doi: 10.19723/j.issn.1671-167X.2019.03.004.
8
Imaging and Quantitative Analysis of the Interstitial Space in the Caudate Nucleus in a Rotenone-Induced Rat Model of Parkinson's Disease Using Tracer-based MRI.
Aging Dis. 2017 Feb 1;8(1):1-6. doi: 10.14336/AD.2016.0625. eCollection 2017 Feb.
9
A novel MRI tracer-based method for measuring water diffusion in the extracellular space of the rat brain.
IEEE J Biomed Health Inform. 2014 May;18(3):978-83. doi: 10.1109/JBHI.2014.2308279.
10
Quantitative Visualization of Dynamic Tracer Transportation in the Extracellular Space of Deep Brain Regions Using Tracer-Based Magnetic Resonance Imaging.
Med Sci Monit. 2017 Sep 3;23:4260-4268. doi: 10.12659/msm.903010.
引用本文的文献
1
Functional Connectivity Encodes Sound Locations by Lateralization Angles.
Neurosci Bull. 2025 Feb;41(2):261-271. doi: 10.1007/s12264-024-01312-0. Epub 2024 Oct 29.
2
Effects of commonly used analgesics on sleep architecture-A topical review.
Pain. 2024 Mar 5;165(8):1664-73. doi: 10.1097/j.pain.0000000000003201.
3
Comprehensive Analysis of the Spatial Distribution of Gadolinium, Iron, Manganese, and Phosphorus in the Brain of Healthy Rats After High-Dose Administrations of Gadodiamide and Gadobutrol.
Invest Radiol. 2024 Feb 1;59(2):150-164. doi: 10.1097/RLI.0000000000001054. Epub 2023 Dec 30.
4
Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.
Nat Biomed Eng. 2023 Nov;7(11):1350-1373. doi: 10.1038/s41551-023-01061-x. Epub 2023 Jul 6.
5
Fluids and flows in brain cancer and neurological disorders.
WIREs Mech Dis. 2023 Jan;15(1):e1582. doi: 10.1002/wsbm.1582. Epub 2022 Aug 23.
6
The Value of First-Order Features Based on the Apparent Diffusion Coefficient Map in Evaluating the Therapeutic Effect of Low-Intensity Pulsed Ultrasound for Acute Traumatic Brain Injury With a Rat Model.
Front Comput Neurosci. 2022 Jun 23;16:923247. doi: 10.3389/fncom.2022.923247. eCollection 2022.
7
Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis.
Front Neurol. 2021 Dec 13;12:767470. doi: 10.3389/fneur.2021.767470. eCollection 2021.
8
Early changes to the extracellular space in the hippocampus under simulated microgravity conditions.
Sci China Life Sci. 2022 Mar;65(3):604-617. doi: 10.1007/s11427-021-1932-3. Epub 2021 Jun 24.
9
Fluid transport in the brain.
Physiol Rev. 2022 Apr 1;102(2):1025-1151. doi: 10.1152/physrev.00031.2020. Epub 2021 May 5.
10
Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats.
Sci Rep. 2020 Dec 28;10(1):22385. doi: 10.1038/s41598-020-79374-z.
本文引用的文献
1
Synaptic clustering within dendrites: an emerging theory of memory formation.
Prog Neurobiol. 2015 Mar;126:19-35. doi: 10.1016/j.pneurobio.2014.12.002. Epub 2015 Jan 8.
2
Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging.
J Control Release. 2015 Jan 10;197:78-86. doi: 10.1016/j.jconrel.2014.10.034. Epub 2014 Nov 7.
3
Astrocytes and extracellular matrix in extrasynaptic volume transmission.
Philos Trans R Soc Lond B Biol Sci. 2014 Oct 19;369(1654):20130608. doi: 10.1098/rstb.2013.0608.
4
A novel MRI tracer-based method for measuring water diffusion in the extracellular space of the rat brain.
IEEE J Biomed Health Inform. 2014 May;18(3):978-83. doi: 10.1109/JBHI.2014.2308279.
5
Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories.
J Neurosci. 2014 May 7;34(19):6647-58. doi: 10.1523/JNEUROSCI.5390-13.2014.
6
Sleep disturbances after cerebral infarction: role of depression and fatigue.
J Stroke Cerebrovasc Dis. 2014 Aug;23(7):1949-55. doi: 10.1016/j.jstrokecerebrovasdis.2014.01.029. Epub 2014 May 1.
7
Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine.
J Neurosci. 2014 Jan 29;34(5):1879-91. doi: 10.1523/JNEUROSCI.2870-12.2014.
8
Use of an extracellular, ion-selective, vibrating microelectrode system for the quantification of K(+), H (+), and Ca (2+) fluxes in maize roots and maize suspension cells.
Planta. 1992 Nov;188(4):601-10. doi: 10.1007/BF00197055.
9
Physiological roles of aquaporin-4 in brain.
Physiol Rev. 2013 Oct;93(4):1543-62. doi: 10.1152/physrev.00011.2013.
10
Sleep drives metabolite clearance from the adult brain.
Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224.
Zotero 插件