Dardik B N, Shainoff J R, Chatelain R E, DiBello P M, Ferrario C M
Cleve Clin J Med. 1989 Jun;56(4):451-6. doi: 10.3949/ccjm.56.4.451.
Electrophoretic profiles of the molecular weight distributions of fibrinogen derivatives in blood provide a tool for combined assessment of coagulation and fibrinolysis in the course of vascular disease. Profiles obtained in studies on an experimental model of hypertension and in humans with occlusive vascular disease are discussed. In the experimental studies elevations in the level of cross-linked dimers provided a more reliable means for predicting development of malignant hypertension than did many other criteria, especially near the outset when blood pressure changed to similar degrees in rats with malignant and benign hypertension. Similarly, we find that levels of dimeric and occasionally trimeric forms of fibrinogen are more prominently elevated than degraded forms of fibrinogen in patients with occlusive vascular disease.
血液中纤维蛋白原衍生物分子量分布的电泳图谱为评估血管疾病过程中的凝血和纤溶提供了一种综合手段。本文讨论了在高血压实验模型研究以及患有闭塞性血管疾病的人类研究中所获得的图谱。在实验研究中，交联二聚体水平的升高比许多其他标准更可靠地预测恶性高血压的发展，特别是在恶性高血压和良性高血压大鼠血压变化程度相似的初期。同样，我们发现，在患有闭塞性血管疾病的患者中，纤维蛋白原的二聚体水平，偶尔还有三聚体水平，比纤维蛋白原的降解形式升高得更显著。
