Ma Zegang, Wang Guilin, Cui Lin, Wang Qimin
Department of Physiology, Medical College of Qingdao University, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao 266071, China.
Int J Mol Sci. 2015 Nov 30;16(12):28377-85. doi: 10.3390/ijms161226102.
Increasing evidence has shown that oxidative stress may be implicated in chronic stress-induced depression. Several flavonoids with anti-oxidative effects have been proved to be anti-depressive. Myricetin is a well-defined flavonoid with the anti-oxidative, anti-inflammatory, anti-apoptotic, and neuroprotective properties. The aim of the present study is to investigate the possible effects of chronic administration of myricetin on depressant-like behaviors in mice subjected to repeated restraint (4 h/day) for 21 days. Our results showed that myricetin administration specifically reduced the immobility time in mice exposed to chronic stress, as tested in both forced swimming test and tail suspension test. Myricetin treatment improved activities of glutathione peroxidase (GSH-PX) in the hippocampus of stressed mice. In addition, myricetin treatment decreased plasma corticosterone levels of those mice subjected to repeated restraint stress. The effects of myricetin on the brain-derived neurotrophic factor (BDNF) levels in hippocampus were also investigated. The results revealed that myricetin normalized the decreased BDNF levels in mice subjected to repeated restraint stress. These findings provided more evidence that chronic administration of myricetin improves helpless behaviors. The protective effects of myricetin might be partially mediated by an influence on BDNF levels and might be attributed to myricetin-mediated anti-oxidative stress in the hippocampus.
越来越多的证据表明，氧化应激可能与慢性应激诱导的抑郁症有关。几种具有抗氧化作用的黄酮类化合物已被证明具有抗抑郁作用。杨梅素是一种具有明确抗氧化、抗炎、抗凋亡和神经保护特性的黄酮类化合物。本研究的目的是探讨长期给予杨梅素对反复约束（每天4小时）21天的小鼠抑郁样行为的可能影响。我们的结果表明，在强迫游泳试验和悬尾试验中，给予杨梅素可特异性减少暴露于慢性应激的小鼠的不动时间。杨梅素治疗可改善应激小鼠海马中谷胱甘肽过氧化物酶（GSH-PX）的活性。此外，杨梅素治疗可降低反复约束应激小鼠的血浆皮质酮水平。还研究了杨梅素对海马中脑源性神经营养因子（BDNF）水平的影响。结果显示，杨梅素可使反复约束应激小鼠降低的BDNF水平恢复正常。这些发现提供了更多证据，表明长期给予杨梅素可改善无助行为。杨梅素的保护作用可能部分通过对BDNF水平的影响介导，可能归因于杨梅素介导的海马抗氧化应激作用。
