Hu Y-J, Luo X-Y, Yang Y, Chen C-Y, Zhang Z-Y, Guo X
Department of Head and Neck Surgery, Tangshan Gongren Hospital, Tangshan, Hebei Province, China.
Emergency Department, Kailuan General Hospital, Tangshan, Hebei Province, China.
Genet Mol Res. 2015 Nov 30;14(4):15325-30. doi: 10.4238/2015.November.30.9.
The aim of this study was to examine the expression of mucin 1 (MUC1) and c-myc and the significance thereof in elderly patients with papillary thyroid carcinoma. The expression levels of MUC1 and c-myc were examined by immunohistochemical methods in 58 patients with papillary thyroid carcinoma, 35 with nodular goiter, and 30 subjects with normal thyroid tissue. The positive rate of MUC1 detection in papillary thyroid carcinoma was 77.6% (45/58), while it was 90.0% (9/10) in those with infiltration and 88.2% (15/17) in those with lymphatic metastasis. The positive rate of c-myc was 81.0% (47/58) in those with papillary thyroid carcinoma and 100.0% (17/17) in those with lymphatic metastasis. These results demonstrated that there were differences in MUC1 and c-myc expression in benign and papillary thyroid carcinoma and that these differences were related to thyroid cancer lymphatic metastasis.
本研究旨在检测黏蛋白1（MUC1）和c-myc在老年甲状腺乳头状癌患者中的表达情况及其意义。采用免疫组化方法检测58例甲状腺乳头状癌患者、35例结节性甲状腺肿患者及30例正常甲状腺组织患者中MUC1和c-myc的表达水平。甲状腺乳头状癌中MUC1检测阳性率为77.6%（45/58），浸润患者中为90.0%（9/10），有淋巴转移患者中为88.2%（15/17）。甲状腺乳头状癌患者中c-myc阳性率为81.0%（47/58），有淋巴转移患者中为100.0%（17/17）。这些结果表明，MUC1和c-myc在良性及甲状腺乳头状癌中的表达存在差异，且这些差异与甲状腺癌淋巴转移有关。
